The Port of Coatzacoalcos has a privileged geographic location in the region of the Istmo de Tehuantepec; it is located at the tip of the shortest land route between the Pacific Ocean and the Gulf of Mexico, at a distance of only 302 km. It is located on the left bank of the river with the same name, which flows into the Gulf of Mexico.

The municipality of Coatzacoalcos is located in the south of the state of Veracruz, at the coordinates 18° 09' north latitude and 94°26' west longitude at an altitude of 10 meters above sea level. It has an area of 471.16 km2, which represents 1% of the total state area.

It borders on the towns Pajápan, Cosoleacaque, Minatitlan, Ixhuatlán del Sureste, Moloacán and Las Choapas; in the north on the Gulf of Mexico, and in the east on the state of Tabasco. The distance by road to the state capital is about 420 km.

The Port of Coatzacoalcos is located in the Isthmus Area and at the southeastern border of the state of Veracruz. Geographically, it is a strategic point that connects the Gulf of Mexico with the Pacific Ocean by road until the cities of Tehuantepec and Salina Cruz in the state of Oaxaca.

In the north, the port premises adjoin to residential areas of the city of Coatzacoalcos, in the south to shipyards of the Mexican Navy (Secretaría de Marina), in the east to the left bank of the river, having in front of it the oil complex Pajaritos and in the west with urban districts.

The port premises cover an area of 352.0 hectares, of which 122.3 are land and 229.7 are water areas.