The port has a connection by railway to the cities of Tuxtepec/ Oaxaca, Veracruz/ Veracruz, Puebla/ Puebla and Mexico City, through the Ferrocarril del Sureste (Ferrosur) (Southeastern Railway).

The Ferrocarril del Istmo de Tehuantepec (FIT ) (Railroad of the Isthmus of Tehuantepec) is connected with the Chiapas Mayab Railway (FCM) in Coatzacoalcos/ Veracruz and Ixtepec/ Oaxaca and with Ferrosur in Medias Aguas/ Veracruz. The FIT has a total length of 303.3 km, of which 95.9 belong to Ferrosur, between Coatzacoalcos and Medias Aguas. In addition, there are short routes that connect Coatzacoalcos with Tenosique/ Tabasco and Campeche/ Campeche as well as with Merida and Progreso/Yucatán.